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KMID : 1123820090110010019
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Health & sports medicine
2009 Volume.11 No. 1 p.19 ~ p.26
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Correlates of BNP and cardiac function after 12-weeks exercise training in patient with chronic heart failure
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Lee Han-Joon
Park Kae-Soon
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Abstract
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The purpose of this study was to analyze the correlation be-tween cardiac function and BNP of patients with chronic heart failure. Eighteen patients participated in this study con-sisting of men group(N=9) and women group(N=9). Exercise program was consisted of aerobic exercise and strength ex-ercise for 12 weeks. We were measured left ventricular ejec-tion fraction(EF), left ventricular cavity volume(LVESV, LVEDV), mitral flow velocity(E, A, E/A, DT) and brain na-triuretic peptide(BNP) before and after 12 weeks of exercise training. Paired t test was performed for each parameter. For compared with between groups, ANCOVA was performed and Pearson correlation was used to correlate BNP and others. BNP was decreased significantly after 12 weeks in women group(p<.05). There were no significant differences between the two groups. But BNP was positively associated with LVEDV(r=.705, p<.05) in men group, and positively as-sociated with LVESV(r=.811, p<.01), LVEDV(r=.897, p<.01) in women group. We concluded that improvements in systolic and diastolic function may reduce BNP after exercise train-ing, and BNP was correlated with LVESV and LVEDV.
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KEYWORD
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BNP, cardiac function, exercise, CHF
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